The impact of confinement by COVID-19 on the academic year. Case study: Gypsy pupils

The urgent virtualisation of academic activity in educational centres forced by the confinement decreed in Spain between the months of March and May 2020 posed a challenge previously unknown to the entire educational community. Information and communication technologies became essential tools to guarantee the continuity of the course. This situation highlighted the lack of technological equipment for the most vulnerable groups of the population and further increased the << digital divide >>, putting at risk the monitoring and school performance of pupils in these sectors. Among the most affected groups is that of gipsy students, as demonstrated in schools such as CEIP Nueva Segovia, (Segovia, Spain). This paper is the result of a qualitative and quantitative research carried out in this school, which has made it possible to identify and analyse the technological devices available to gipsy students, the perception of the different members of the educational community on the use of technologies and, finally, the training of these members in relation to new technologies. The results reveal the needs not only for equipment, but also for training in new technologies that both families and students have. These results show the importance of a new curricular approach for pupils with educational compensation needs to eliminate this situation of inequality.

Mobilizing Social Media Data: Reflections of a Researcher Mediating between Data and Organization

This paper examines the practices involved in mobilizing social media data from their site of production to the institutional context of non-profit organizations. We report on nine months of fieldwork with a transnational and intergovernmental organization using social media data to understand the role of grassroots initiatives in Mexico, in the unique context of the COVID-19 pandemic. We show how different stakeholders negotiate the definition of problems to be addressed with social media data, the collective creation of ground-truth, and the limitations involved in the process of extracting value from data. The meanings of social media data are not defined in advance;instead, they are contingent on the practices and needs of the organization that seeks to extract insights from the analysis. We conclude with a list of reflections and questions for researchers who mediate in the mobilization of social media data into non-profit organizations to inform humanitarian action. © 2023 ACM.

[Cryptogenic new-onset super-refractory status epilepticus following SARS-CoV-2 vaccination. A case report]. / Estado epiléptico superrefractario de nueva aparición criptógeno tras vacunación contra el SARS-CoV-2. A propósito de un caso.

INTRODUCTION: New-onset super-refractory status epilepticus (NOSRSE) is a neurological emergency characterised by the development of status epilepticus in a patient without epilepsy or any known prior neurological disease and with no clear structural, toxic or metabolic cause, which recurs after 24 hours of induced coma. The most common identifiable cause is inflammatory-autoimmune. Consequently, we present a case of NOSRSE related to SARS-CoV-2 vaccination as an opportunity to investigate the dysimmune origin of this pathology. CASE REPORT: We report the case of a 40-year-old male who presented at the emergency department with fever and headache with no clear source of infection. His personal history included bacterial meningitis in childhood without any sequelae and protein S deficiency without treatment at the time, as well as vaccination with ChAdOx1 nCoV-19 21 days earlier. He was initially diagnosed with a urinary tract infection and treated with cefuroxime. Two days later, he was taken back to the emergency department with confusional symptoms and tonic-clonic seizures. He did not respond to midazolam and finally required sedation and orotracheal intubation for refractory status epilepticus. While in hospital, he required a number of lines of antiepileptic drugs, ketamine, a ketogenic diet, immunotherapy and plasmapheresis in order to successfully limit NOSRSE. The aetiological study offered normal results for serology, antineuronal antibodies in serum and cerebrospinal fluid, transthoracic echocardiography, testicular ultrasound and computed tomographic angiography. Only the control MRI scan showed a diffuse and bilateral alteration of the right hemispheric cortex and thalamic pulvinar as the only finding. CONCLUSION: It is crucial to report suspected adverse reactions associated with SARS-CoV-2 vaccination, thereby allowing continued monitoring of the risk/benefit ratio of vaccination.

TITLE: Estado epiléptico superrefractario de nueva aparición criptógeno tras vacunación contra el SARS-CoV-2. A propósito de un caso.Introducción. El estado epiléptico superrefractario de nueva aparición (NOSRSE) es una emergencia neurológica caracterizada por el desarrollo de estado epiléptico en un paciente sin epilepsia ni enfermedad neurológica previa conocida y sin clara causa estructural, tóxica o metabólica, que recurre tras 24 horas del coma inducido. La causa identificable más frecuente es la inflamatoria-autoinmune. En consecuencia, planteamos un caso de NOSRSE relacionado con la vacunación para el SARS-CoV-2 como una oportunidad de indagar el origen disinmune de esta patología. Caso clínico. Varón de 40 años que acude al servicio de urgencias refiriendo fiebre y cefalea sin claro foco infeccioso. Entre sus antecedentes personales destacamos una meningitis bacteriana en la infancia sin secuelas y un déficit de proteína S sin tratamiento en ese momento, así como vacunación con ChAdOx1 nCoV-19 21 días antes. Fue inicialmente diagnosticado de infección del tracto urinario y tratado con cefuroxima. Dos días después, se le llevó de nuevo a urgencias con cuadro confusional y crisis tonicoclónicas, sin respuesta al midazolam, y requirió finalmente sedación e intubación orotraqueal por estado epiléptico refractario. Durante su ingreso requirió múltiples líneas de antiepilépticos, quetamina, dieta cetógena, inmunoterapia y plasmaféresis para conseguir limitar el NOSRSE. El estudio etiológico ofrecía normalidad de los resultados de serología, anticuerpos antineuronales en el suero y líquido cefalorraquídeo, ecocardiografía transtorácica, ecografía testicular y angiotomografía computarizada. Únicamente la resonancia magnética de control mostró una alteración difusa y bilateral de la corteza hemisférica y pulvinar talámica derecha como único hallazgo. Conclusión. Es crucial notificar las sospechas de reacciones adversas asociadas a la vacunación frente al SARS-CoV-2, permitiendo así una supervisión continuada de la relación riesgo/beneficio de ésta.

Case-fatality rate of SARS-CoV-2 infection during the third and fifth epidemic waves in Spain: Impact of vaccination.

INTRODUCTION: During the first and second epidemic waves in Spain, the SARS-CoV-2 case-fatality rates (CFRs) showed significant differences between Autonomous Communities (ACs). Comparing CFRs in the third and fifth epidemic waves can provide information on the impact of the different vaccination coverages in the ACs. OBJECTIVE: To evaluate the impact of vaccination on COVID-19 CFRs in the third and fifth epidemic waves in Spain, according to sex, age, and AC. METHODS: This work is an observational, descriptive study which uses data on COVID-19 infections, deaths, and vaccinees published by the Spanish Ministry of Health and the regional Health Departments of the ACs. The third epidemic wave was defined as the period from 26th December 2020 to 19th April 2021, and the fifth wave, from 19th July to 19th September 2021. The CFRs (deaths per 1000 infected [‰]) were calculated according to sex, age group, and AC. The standardized case-fatality ratio (SCFR) was adjusted for age and sex for each wave. We estimated the correlation between CFRs and their change between the two epidemic waves with the vaccination coverages reached at the beginning of the fifth wave. RESULTS: The CFR in the fifth wave (5.7‰) was lower than in the third wave (16.5‰). In addition, the CFR in both waves was significantly higher in men than in women, and in older people than in younger ones. A decrease in the CFR between both waves was only observed in those older than 49. A strong direct and positive correlation (R2a=0.8399) was found between vaccination coverage by age group and decrease in CFR between both epidemic waves. Significant differences were seen between ACs in the two waves, as regards both CFRs and SCFRs. When comparing ACs, a direct correlation was observed between vaccination coverage and CFRs in the fifth wave, and also - although weak - between vaccination coverage and decrease in CFR between both waves. CONCLUSION: The CFR significantly decreased in Spain between the third and the fifth epidemic waves in population aged 50 or older, probably due to the high vaccination coverage in that age group. Differences were observed between CFRs and SCFRs between ACs that are not explained by the differences in vaccination coverage, suggesting the need for further research and evaluation.

Students with Disabilities in the Digital Society: Opportunities and Challenges for Inclusive Education

This chapter focuses on access to the educational system for students with special educational needs derived from disability and the role ICT can play in facilitating educational inclusion. ICT could become an additional factor of exclusion if the design of technological solutions is not universal. It also analyzes the impact of the implementation of distance education modalities and the generalization of ICT use in teaching during the COVID-19 pandemic on students with disabilities. It concludes that students with disabilities should be a priority objective in the digitalization plans of schools. If the future educational systems are built without an inclusive perspective, they will likely reproduce the same deficiencies of the present. Beyond responding to the crisis caused by COVID-19, the incorporation of technology and efforts to implement distance learning at all levels of education provide valuable lessons and lay the foundation for building more open, inclusive, and flexible educational systems. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021.

Variations in aim and catch values in 11-and 12-year-old children in northern Spain during SARS-CoV-2 loc-kdown

Some habits related to diet, PA practice and screen time were modified as a consequence of the appea-rance of SARS-CoV-2 in Spain, especially in the infant--jupanielvenile population. These changes resulted in lower levels of physical activity and increased time spent in sedentary activities during lockdown, which lasted 4 months between March and June 2020. The aim of this study was to determine the impact on the aiming and catching of 11-12 year old school children during this lockdown. Methods: The study involved 50 children aged 11-12 years (M = 11.40, SD = 0.50), 33 (66%) boys and 17 (34%) girls from northern Spain. The Movement Assessment Battery for Children 2 (Movement ABC-2) was used for data collection as well as an ad hoc socio-demographic questionnaire. Results: There were significant differences (p < 0.05) in the results for the aiming and catching variables measured by the tests established by the MABC-2 in the total sample as well as by gender. There were also significant differences in the boys and girls of the sample in mean, scalar and percentile scores for aiming and catching between pre-lockdown and post-lockdown, with a more pronounced worsening of the measured values in girls than in boys. Conclusions: The study showed a significant worsening of aiming and catching values in boys and girls aged 11-12 years during SARS-CoV-2 lockdown. © 2023, LIECREH GUTH. All rights reserved.

Impact of COVID-19 on Education: Evolution of Virtual Laboratories

Extensive research has demonstrated the importance of e-learning during COVID-19. However, a study to check whether the virus has caused a trend change in educational research lines is lacking. This paper reviews the temporal evolution of publications on virtual laboratories (VLs) in education, analyzing the relationship between its recent boom and the advent of COVID-19. For this purpose, a bibliographic study was carried out in the Scopus database seeking different VLs synonyms in the title, , and keywords of articles published between 1990 and 2022. The analysis results determine that the logistical needs imposed by the COVID-19 pandemic have been found to magnify the use of VLs, increasing scientific production by more than 90% in 2021 compared to the average obtained between 2011-2020. It has also been estimated that with the return to face-to-face teaching, production has decreased by 20% in 2022 compared to 2021. © 2023 IEEE.

Pharmacokinetics Informs Remdesivir Dosing for Patients with Severe Renal Impairment

Background: Despite renal impairment (RI) being a risk factor for severe COVID-19, there are no approved antiviral treatment options for patients with severely impaired kidney function (eGFR less than 30 mL/min/1.73 m2 or kidney failure) in the US. At the time remdesivir (RDV) was initially approved for the treatment of COVID-19, the impact of renal impairment (RI) on pharmacokinetics (PK) of RDV, its metabolites, and the excipient, sulfobutylether beta-cyclodextrin sodium (SBECD), was not known. Method(s): Here, we report the PK data supporting dosing of RDV in COVID-19 patients with severely impaired kidney function. PK samples for RDV and metabolites (GS-704277, GS-441524) were collected in the Phase 3 REDPINE study in hospitalized COVID-19 patients with severely impaired kidney function. Participants in this double-blind study were randomized 2:1 to intravenous (IV) remdesivir (200 mg on Day 1, then 100 mg daily up to Day 5) or IV saline as placebo-to-match. SBECD PK was analyzed in a phase 1 study in non-COVID-19 participants with normal kidney function, mild and moderate RI who received 100 mg dose of remdesivir (containing 3000 mg SBECD). The population PK analysis included observations from healthy and COVID-19 patients with full range of renal function across all adult studies. Result(s): Geometric mean exposures (AUCtau) observed in REDPINE Study as compared to PINETREE Study increased up to 553% for the GS-441524 metabolite (dependent on renal elimination) and to a lesser degree GS-704277 (294%, minor renal elimination) and RDV (78.9%;an increase explained by factors other than renal function, namely, hospitalization and body weight) (Table 1). The increased PK exposures were not associated with new safety signals in this study (n=163 remdesivir, n=80 placebo). Population PK analysis identified baseline eGFR as a significant covariate for GS-704277 and GS-441524 clearance, but not for RDV itself. SBECD PK was characterized by short half-life (t1/2) (1.6 hours in normal renal function to 3.8 hours in moderate RI) and fast plasma clearance (7.9 L/h in normal renal function). Analysis of SBECD in severe RI (REDPINE) is ongoing, but accumulation is not expected based on its observed short plasma t1/2. Conclusion(s): Given the observed PK and the absence of any new safety signals associated with increased metabolite levels in patients with severely impaired kidney function, no dose adjustment is recommended for RDV in COVID-19 patients with eGFR < 30 mL/min/1.73 m2, regardless of the need for dialysis.

From Covid to Bovid to Ovid: A Case of Disseminated Cryptococcus Neoformans

Case Report: Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus, with C. neoformans and C. gattii being the most common species to cause human disease. Immunocompromised individuals are predisposed to infections with C. neoformans, which has known predilection to CNS and pulmonary lymph nodes. We present a unique case of disseminated cryptococcosis in the setting of end-stage renal disease (ESRD), cirrhosis, tumor necrosis factor inhibitor use and steroid use for COVID19. Method(s): A single-patient case report was conducted after IRB approval. Case Presentation: A 55-year-old woman with uncontrolled diabetes, lupus, rheumatoid arthritis on adalimumab, hepatitis C status post boceprevir, cirrhosis, former IV drug use, and ESRD on hemodialysis via bovine arterial-venous fistula graft presented with worsening dyspnea, cough, and altered mental status. Three months prior, patient was admitted to an outside hospital for COVID19, complicated by pulmonary embolism status post anticoagulation therapy. Patient was treated with an unknown steroid regimen, which was continued by a second outside facility when symptoms failed to improve. Patient then presented to our facility 24 hours after discharge due to continued symptoms. On admission, patient was noted to have altered mentation and hypoxia with pulmonary edema on chest x-ray and was urgently hemodialyzed. Further work-up was obtained due to non-resolving symptoms, including blood and sputum cultures, cocci serology and QuantiFERON gold. CT chest revealed bilateral consolidations. Patient was started on antibiotics for presumed hospital-acquired pneumonia. During the hospital stay, preliminarily blood cultures grew yeast and patient was started on Micafungin. However, Micafungin was changed to Liposomal Amphotericin B as ovoid structures seen on gram stain could not confirm nor rule out cryptococcus. Subsequent bronchial wash and bronchoalveolar lavage cultures, as well as final blood cultures resulted Cryptococcus neoformans. Serum cryptococcus antigen returned reactive, titer 1:512. Antibiotics were discontinued and Isavuconazonium was started with Liposomal Amphotericin B. Due to recurrent headaches, lumbar puncture was obtained and revealed lymphocytic pleocytosis without cryptococcal antigenicity. Patient completed 14 days of Liposomal Amphotericin B and Isavuconazole with continuation of Isavuconazole upon discharge. Conclusion(s): Disseminated cryptococcosis in non-HIV patients is rare in the modern HIV era. Clinicians should be aware and include it in their differential of any patient with multiple risk factors for opportunistic infection. In patients with cirrhosis and ESRD, treatment is limited given altered pharmacokinetics. Studies have shown improved survival with the addition of Isavuconazole in patients with disseminated cryptococcosis with CNS involvement in the setting of chronic liver disease and ESRD.

Challenges and Results of Haploidentical Stem Cell Transplantation for Adult Patients in Cuba

The Hermanos Ameijeiras Hospital (HAH) in Havana is the only center performing allogeneic hematopoietic stem cell transplantation (HSCT) in adult patients in Cuba. Because transplants from unrelated donors are not possible due to political restrictions and economic embargo, in 2016 HAH and University of Illinois at Chicago (UIC) started a collaboration to support the training of a physician, annual educational programs and exchange of guidelines and protocols to perform haploidentical transplants. The first haploidentical transplant was performed at HAH in 2016. Because of limited resources, disease risk stratification is based on morphologic assessment, as cytogenetic is tested on an irregular basis. Peripheral blood stem cells (PBSC) were infused based on total nucleated cell count (TNC) due to lack of reagents for flow cytometry. Posttransplant chimerism and CMV monitoring cannot be performed. Transplant activity was stopped in 2020 due to high expenses allocated for COVID19 pandemic in Cuba. From 2016 to 2020, 16 haploidentical HSCT in 15 patients (9 males/ 6 females) were completed at HAH. The median age of patients was 34 years (range:21-54). Diagnoses included: acute leukemia, n=12, myelodysplastic syndrome, n=1, Hodgkin disease, n=1, and severe aplastic anemia, n=1. At the time of transplant, 11 patients were in morphologic remission and 5 had active disease. Conditioning regimens utilized were myeloablative (Flu/Bu) in 10 cases and at reduced intensity (Flu/Cy/ TBI200 +/- ATG) in 6 cases, and GVHD prophylaxis was standard PTCy on D3 and 4, CsA and mycophenolate. The donors were mother (n=10), father (n=1), child (1), or sibling (n=3) and the median age was 48 years (range: 26-68). All patients received fresh stem cells from PBSC(n=13) or bone marrow (n=3). Median cell dose infused was 5.5x108 TNC/kg (range: 2.2-8). All patients but 1 engrafted and median time to neutrophil and platelet engraftment was 17 days (range:12-28) and 16 days (range:11-30), respectively. Acute graft-versus-host disease (GVHD) grade 2-3 occurred in 50% of patients and chronic GVHD in 2 out of 8 that were evaluable. Day 100 and 2-year overall survival rates were 73% and 40%, respectively. With a medium follow-up of 18.8 months (range: 0.3-64), 5 of 15 patients (30%) are alive and complete remission. Causes of death in the remaining 10 patients included relapse of original disease, n= 4;bacterial infection, n=2;brain hemorrhage, n=1;VOD, n=1;graft failure, n=1;and multi-organ failure, n=1. Despite significant difficulties, HAH implemented a haploidentical transplant program for adult patients in Cuba. Among future steps, improving access to molecular testing and using younger donors will be pursued to improve on the results. The partnership between HAH and UIC has been instrumental in building clinical and research capacity and continues to support HAH in its mission to provide care to patients in Cuba.(Figure Presented)Copyright © 2023 American Society for Transplantation and Cellular Therapy

Covid-19 pandemic impact in pediatricians: stress factors and their consequences

Previous studies have demonstrated that the COVID-19 pandemic has had negative psychological consequences on healthcare professionals, however, specific data on pediatricians are scarce. Ob-jective: To evaluate anxiety among pediatricians after the first COVID-19 wave as well as to identify possible related risk factors. Material and Method: A cross-sectional multicentric survey study was designed and sent to Spanish pediatricians through the Asociacion Espanola de Pediatria's e-mail lists. Demographic, socio-familial, occupational, emotional self-perception, psychosomatic symptoms, smoking, alcohol, and psychotropic drugs use data were collected. The State-Trait Anxiety Scale (STAI) was included, and its association with qualitative and quantitative variables of the sample was studied. Results: 440 surveys were registered. 42.2% of the participants expressed moderate-intense anxiety symptomatology according to the Anxiety-State scale and 26.9% on the Anxiety-Trait scale. Isolation at home was associated with a higher score on both scales. A change in the work situation of the cohabitant resulted in a higher score on the Anxiety-State scale. 41.1% of the respondents clas-sified the psychological impact suffered as mild, 50% as moderate, and 8.9% as severe. Up to 71.8% of the participants manifested some psychosomatic symptoms, with a linear association between the concurrence of symptoms and higher scores on the two scales. Conclusions: After the first pandemic wave, pediatricians have suffered anxiety, causing physical and emotional discomfort. Personal sit-uations were the main source of concern. Likewise, the presence of several somatic symptoms was associated with higher levels of anxiety.

Assessment of humoral and cellular immunity after bivalent BNT162b2 vaccination and potential association with reactogenicity

Nowadays, new challenges around increasing production quality and productivity, and decreasing energy consumption, are growing in the manufacturing industry. In order to tackle these challenges, it is of vital importance to monitor the health of critical components. In the machine tool sector, one of the main aspects is to monitor the wear of the cutting tools, as it affects directly to the fulfillment of tolerances, production of scrap, energy consumption, etc. Besides, the prediction of the remaining useful life (RUL) of the cutting tools, which is related to their wear level, is gaining more importance in the field of predictive maintenance, being that prediction is a crucial point for an improvement of the quality of the cutting process. Unlike monitoring the current health of the cutting tools in real time, as tool wear diagnosis does, RUL prediction allows to know when the tool will end its useful life. This is a key factor since it allows optimizing the planning of maintenance strategies. Moreover, a substantial number of signals can be captured from machine tools, but not all of them perform as optimum predictors for tool RUL. Thus, this paper focuses on RUL and has two main objectives. First, to evaluate the optimum signals for RUL prediction, a substantial number of them were captured in a turning process and investigated by using recursive feature elimination (RFE). Second, the use of bidirectional recurrent neural networks (BRNN) as regressive models to predict the RUL of cutting tools in machining operations using the investigated optimum signals is investigated. The results are compared to traditional machine learning (ML) models and convolutional neural networks (CNN). The results show that among all the signals captured, the root mean squared (RMS) parameter of the forward force ( F-y ) is the optimum for RUL prediction. As well, the bidirectional long-short term memory (BiLSTM) and bidirectional gated recurrent units (BiGRU), which are two types of BRNN, along with the RMS of F-y signal, achieved the lowest root mean squared error (RMSE) for tool RUL, being also computationally the most demanding ones.

Redefinition of Social Ties During the COVID-19 pandemic: Narratives of People who Relate with Each Other in Gated Communities

This article describes the research process that revolves around the resignation of social ties in the narratives of two residential complexes: Arboleda I and Casablanca stage II of the city of Bogota D.C, during the COVID-19. To this end, the current situation is recognized by pointing out the basic conceptions oriented to the COVID-19, from the elements of its emergence, its expansion, the measures taken by the Colombian government, as well as the attitude of civil society in residential complexes. The article covers the understanding of the subjectivities of actors who with their voices relate their experiences around social ties, highlighting the uniqueness of the community, organizational aspects, and technological means, among others. The methodology used is qualitative, in the line of narrative research;Subsequently, a relational analysis leads to results that show the different modifications that the inhabitants have experienced in the way of linking at the branch level, selective, organic and citizen participation in times of health emergency.

Ensayo clínico aleatorizado en pacientes COVID- 19 sobre el efecto de la fisioterapia precoz en su acondicionamiento físico

Introduction: The WHO recommends early rehabilitation and mobilization interventions in patients hospitalized for COVID-19. The benefits of early physiotherapy, during the hospital stay, have not been proven in clinical trials. Objective: To evaluate the effects of early physiotherapy and health education in hospitalized COVID-19 patients, in relation to the symptoms described in previous studies, analyzing differences between groups regarding their physical conditioning, need for oxygen therapy and hospital stay. Methodology: Randomized clinical trial with two arms, developed in hospitalization and intermediate respiratory care units, with COVID-19 patients. Sixty-four patients included in the experimental group (implementation of an early physiotherapy program after 48–72 h of admission) and 62 patients in the control group (usual treatment of the center). Sociodemographic and clinical variables: mMRC, oxygen therapy, MRC-SS, 30 s-STST, FPM, Tinetti, FRAIL Scale and PCFS. They were evaluated on admission, discharge and two months after discharge. Results: The experimental patients had fewer days of admission and conventional oxygen therapy. At discharge, they present a lower risk of falling (72.9% vs. 95.8%) and less weakness in MRC-SS (2.1% vs. 14.6%). At two months they had less frailty (5.0% vs. 14.5%), greater hand grip strength, less dyspnea, better results in 30s-STST and fewer post-COVID limitations (86.5% vs. 96.4%). Conclusión: The intervention of early physiotherapy in COVID-19 patients and the health education received, prevents muscle weakness during admission, improves physical conditioning at discharge and two months later, and reduces the days of hospital stay. ClinicalTrials.gov (NCT05032885). © 2023 Asociación Española de Fisioterapeutas

Use of Non-Invasive Respiratory Support Strategies in pediatric patients with SARS-CoV-2. A Scoping Review

Introduction: The use of non-invasive respiratory support strategies (NIRS) has been shown to reduce the consumption of resources associated with the requirement of intensive care unit and hospital stay in pediatric patients with acute respiratory failure, however, it is considered important to identify their frequency of use in pediatric patients with SARSCoV-2 and its relationship with the hospital stay. Objective: To identify the frequency of use of noninvasive respiratory support strategies (NIRS) in pediatric patients with SARS-CoV-2. Material and methods: Scoping review of the frequency of use of NIRS in pediatric SARS-CoV-2 between January 2020 and September 2021. The search was executed in the Cochrane Library, PubMed, Scopus databases, and the bibliographic search engines Science Direct and Oxford. Results: It was found that conventional, follow-up, or high-flow oxygen therapy and noninvasive mechanical ventilation are used more frequently in hospital settings. Conclusion: The NIRS of greater implementation in the pediatric patient with SARS-CoV-2 was conventional oxygen therapy and as a finding of interest its association with higher hospital stays was evidenced. © 2023 Academia Nacional de Medicina. All rights reserved.

Comparative diagnostic performance of the new chromatographic AffimerR-based rapid antigen detection against SARS-CoV-2 and other standard antigen tests for COVID-19 in a clinical setting

The availability of accurate and rapid diagnostic tools for COVID-19 is essential for tackling the ongoing pandemic. In this context, researchers in the UK have started testing a new Lateral Flow Device (LFD) based on proprietary Biotinylated anti SARS-CoV-2 S1 AffimerR technology that binds to the SARS-CoV2-S1 protein in anterior nasal swab samples, generating an ultrasensitive method for detection. This international study aimed to compare its performance against other available Antigen-detecting Rapid Diagnostic Tests (Ag-RDTs) in a real-world clinical setting. The study was completed under the frame of Project SENSORNAS RTC-20176501 in collaboration with MiRNAX Biosens Ltd. and Hospital Carlos III, it was documented internally and deposited in agreement to the ISO 13485 norm. All the data obtained are currently under submission and review from the Ethics Committee of Universidad Autonoma de Madrid.

Corporate social responsibility in the Covid era. An exploratory literature review

COVID-19 has shaken every nation in the world, and its consequences have spread throughout society. The influence of the health pandemic has left a negative imprint on both the public and private sectors, affecting thousands of people. The objective of this literature review is to explore, summarise, and analyse the state of the art of corporate social responsibility (CSR) practices in the context of COVID-19 by identifying those that have been implemented during the pandemic. This review was developed using the narrative method to gain a broader perspective of this phenomenon by analysing 30 Web of Science (WOS) articles from 1998 to 2020. The findings suggest that the implementation of CSR-focussed practices offers the possibility to change consumer behaviour towards a socially responsible approach, thus contributing to our country's economic recovery. The inclusion of CSR within the COVID context allows for a better understanding of the socially responsible practices that have been implemented during the health restrictions. © 2022 Emerald Publishing Limited. All rights reserved.

Strengthening Brand Equity in Hotel Chains: Insights from Emerging Vs. Developed Economies

Today, many consumers seek to stay in environmentally sustainable hotels. Moreover, the tourism industry is one of the most impacted by the COVID-19 outbreak. In this increasingly competitive environment, companies in general, and hotels in particular, must offer unique experiences through value co-creation. The purpose of this work is to analyze the impact of "green” practices and value co-creation on brand equity, evaluating the moderating role of the consumer's nationality in the setting of hospitality companies. From a personal survey of 309 hotel guests in Valencia (Spain) and 302 guests in Bogotá (Colombia), evidence is obtained on the existence of some differences depending on the guest's country of origin, thus allowing hotel managers to have a better knowledge when designing their corporate strategies. © 2023 Taylor & Francis Group, LLC.